In Silico Analytic of Antiacne Potential from Jamblang Flower’s Essential Oil Formulation

Nurfadilah Azizah Hasibuan, Diky Setya Diningrat, Ayu Nirmala Sari

Abstract


This study aims to determine the components of compounds contained in Jamblang flower essential oil (Syzygium cumini L.) as antiacne and mechanism of antiacne. Jamblang flower essential oil is obtained through a distillation process. The distilled oil was then analysed using a Gas Chromatography Mass Spectrophotometer (GC-MS). Analysis results GC-MS evaluated using the program MASSLAB. Data obtained from the tool GC-MS then analysed using software PubChem NCBI database (https://pubchem.ncbi.nlm.nih.gov/) and PASS Online. The results of the GC-MS analysis showed that there were 47 bioactive compounds in Jamblang flower essential oil. Analysis results PubChem showed 13 compounds have activity as an antibacterial. Analysis results PASS Online demonstrated an antibacterial mechanism, protein synthesis inhibitor, membrane permeability inhibitor dan cell wall synthesis inhibitor, with the highest Pa value of 0.804 in the compound Benzyl benzoate $$Benzoic acid, phenylmethyl ester (CAS) and lowest Pa value in 1H-Benzimidazole,2-(methylthio)-(CAS)$$2-thiomethylbenzimidazole.


Keywords


acne vulgaris; antibacterial activity; flavonoid; GC-MS; jamblang; PASS online; Syzigium cumini

Full Text:

PDF

References


Ayyanar, M., and Pandurangan, SB. (2012). Syzygium cumini (L.) Skeels: A review of its fitochemical constituents and traditional uses. Asian Pacific Journal of Tropical Biomedicine, 2(3), 240-243.

Dalimartha, S. (2003). Atlas tumbuhan obat Indonesia Jilid 3. Jakarta: Trubus Agriwidya. Departemen Kesehatan Republik Indonesia.

Darmapatni, K. A. G., Basori, A., and Suaniti, N. M. (2016). Pengembangan metode GC-MS untuk penetapan kadar acetaminophen pada spesimen rambut manusia. Jurnal Biosains Pascasarjana, 18(3), 255–265.

Hendartomo. (2005). Pengambilan minyak atsiri dari daun dan ranting Nilam (Posgostemon Cablin benth) dengan cara penyulingan uap. Artikel Penelitian. Jogjakarta

Julianto, T. S. (2016). Minyak atsiri bunga Indonesia (Edisi 2). Depublish Publisher, Yogyakarta, 197-200.

Fitriani, S., Diningrat, D. S., Sari, A. N., Harahap, N. S., and Kusdianti, K. (2023). Aktivitas biologis minyak esensial daun dan biji Jamblang (Syzygium cumini) dan potensinya sebagai antivirus SARS-CoV-2 Secara in silico. Kalwedo Sains, 4(1), 17-30.

Magdy I. Mohamed. (2004). Optimization of Chlorpenesin Emugel Formulation. American Association of Pharmaceutical Scientists Journal. 6(3): 81–87.

Ma’sum, Z., and Proborini, D. W. (2016). Optimasi Proses Distilasi Uap Essential Oil. Jurnal Reka Buana, 1(2), 105–109.

Pramely, R., and Raj, T. L. S. (2012). Prediction of biological activity spectra of a few phytoconstituents of Azadirachta indica A. Juss. Journal Biochemical Technology, 3(4), 375–379.

Zaenglein, A. L. (2018). Acne vulgaris. New England Journal of Medicine, 379(14), 1343-1352.

Miksusanti, M., Jennie, B. S. L., Ponco, B., and Trimulyadi, G. (2008). Kerusakan dinding sel Escherichia coli oleh minyak atsiri Temu Kunci (Kaempferia pandurata). Berita Biologi, 9(1), 1-8.

Markham, K. R. (2012). Cara mengidentifikasi flavonoid. Indonesia Medicus Veterinus, 1(3), 337-351.


Refbacks

  • There are currently no refbacks.